Background: Pulsatile pituitary gonadotropin secretion governed by hypothalamic gonadotropin-releasing hormone (GnRH) is essential for the pubertal onset.The epigenetic mechanism underlying the activation of GnRH-dependent regulatory axis in hypothalamus remains elusive.This study aims to explore the potential correlation between the signature of D
Background/Aims Endoscopic submucosal dissection (ESD) for residual or recurrent colorectal lesions after incomplete resection is challenging because of severe fibrosis.This study aimed to compare the efficacy of the pocket-creation method (PCM) with a traction device (TD) with that of conventional ESD for residual or recurrent colorectal lesions.M
Summary: Drug-tolerant persister (DTP) cells have attracted significant interest, given their predominant role in treatment failure.In this respect, DTP cells reportedly survive after anticancer drug exposure, and their DNA repair mechanisms are altered to enhance adaptive mutation, accounting for the emergence of drug-resistant mutations.DTP cells
The spread of antimicrobial resistance (AMR) is a major global concern, and the islands of the Southwest Indian Ocean (SWIO) are not exempt from this phenomenon.As strategic crossroads between Southern Africa and the Indian subcontinent, Color Additive these islands are constantly threatened by the importation of multidrug-resistant bacteria from t
Beer and brewery events are a commercial, marketing and social phenomenon.Besides the consumption of beer, they also offer an interesting cultural Nightwear and gastronomic component and present an opportunity to meet family and friends.The questionnaire survey of motivation of participation in beer and brewery festival confi rmed a number of inter